Gabriel合成法的研究与应用进展

Advances in Research and Applications of Gabriel Synthesis

本文先简单介绍了Gabriel反应,然后分别综述了苄位和烯丙位等活泼卤代烃、伯卤代烃、磺酸酯的Gabriel反应,邻苯二甲酰亚胺与环氧化合物的缩合、含邻苯二甲酰亚胺基的合成子、邻苯二甲酰亚胺与醇在Mitsunobu条件下的直接Gabriel反应等,最后对Gabriel反应的应用进行了总结和展望。指出应加强对Gabriel反应的系统研究,特别是脱邻苯二甲酰基的方法和基于Gabriel反应原理的替代方法的研究。

This paper first introduced Gabriel reaction in brief,then discussed in order Gabriel reactions of active halides such as benzyl- and allyl-halides,primary halides,and sulfonates,Gabriel reactions of phthalimide with epoxy compounds,phthalimidecontaining synthons,and direct reaction of phthalimide with alcohols under Mitsunobu conditions,and finally summarized and overviewed the development of Gabriel reaction. It was pointed out that further and systematic studies for Gabriel reaction and methods for the removal of the phthalimide functionality and replacement methods based on Gabriel reaction principles are clearly needed.