粘细菌纤维堆囊菌的基因组学研究现状

Research Status of Genomics of Myxobacteria Sorangium cellulosum

纤维堆囊菌(S.cellulosum)属于粘细菌中的堆囊菌属,它们能产生丰富的次级代谢产物,而且是目前基因组最大的原核生物,现已测序的S.cellulosum So ce56和So 0157-2分别拥有13.03 Mb和14.78 Mb的环状染色体。本文阐述了这两株纤维堆囊菌在序列的组装验证和基因组的分析注释等方面的完成情况,以及人们在测序的基础上,对其展开的结构基因组学、比较基因组学和功能基因组学的研究。通过介绍这两株已测序纤维堆囊菌的基因组学研究现状,我们总结了从纤维堆囊菌的全基因组序列中挖掘遗传信息的方法,为发现纤维堆囊菌中新的功能基因提供一些参考。

Sorangium cellulosum （S. cellulosum）, which belongs to the genus Sorangium of the group myxobacte- ria, not only has the largest bacteria genome so far but can produce abundant secondary metabolites. From point of view of the S. cellulosum So ce56 and So 0157-2, both genomes are circular chromosomes which are 13.03 Mb and 14.78 Mb, respectively. This paper introduced information on assembly, verifification, analysis and annotation of the complete genome sequence of S. cellulosum. Based on whole genome data, We also summarized the re- search achievement of the sequenced strains in structural genomics, comparative genomics and functional ge- nomics. In this review we mainly introduced the present research status of the sequenced S. cellulosum, which in- cluded the approaches to mine genetic information from the complete genome sequence of these two trains and provided some study cases to detect new functional gene as well.