骨桥蛋白表达与中国人肝癌及其临床病理特征关系的Meta分析

Association between Expression of Osteopontin and Chinese Population with Hepatocellular Carcinoma and Its Clinical Pathological Characteristics:A Meta-Analysis

目的系统评价骨桥蛋白（OPN）表达与中国人肝癌及其临床病理特征的关系。方法计算机检索CBM、CNKI、VIP和Wan Fang Data数据库,搜集有关OPN表达与中国人肝癌及其临床病理特征关系的研究,检索时限均截至2014年7月。由2位研究者按照纳入与排除标准筛选文献、提取资料并评价纳入研究的方法学质量后,采用Rev Man 5.2软件进行Meta分析。结果共纳入10个病例-对照研究,其中肝癌组723例,正常肝组织组102例。Meta分析结果显示：OPN在肝癌组表达较正常对照组高[OR=10.25,95%CI（6.13,17.14）],肝癌包膜不完整组较与包膜完整组表达高[OR=2.71,95%CI（1.58,4.64）];OPN在肝癌单发组与多发组[OR=0.95,95%CI（0.56,1.62）]、高中分化组与低分化组[OR=0.60,95%CI（0.36,1.01）]、临床Ⅰ~Ⅱ期组与临床Ⅲ~Ⅳ期组[OR=0.93,95%CI（0.53,1.63）]的表达差异无统计学意义。结论现有证据表明,OPN可能参与了中国人肝癌发生、发展的全过程,但其是否可作为预后判断的因素,尚待进一步研究。

Objective To systematically review the association between expression of osteopontin（OPN） and Chinese population with hepatocellular carcinoma（HCC） and its clinical pathological characteristics. Methods Such databases including CBM,CNKI,VIP and Wan Fang Data were searched from inception to July 2014,for studies about the association between expression of OPN and Chinese population with HCC and its clinical pathological characteristics. Two reviewers independently screened literature according to the exclusion and inclusion criteria,extracted data,and assessed methodological quality of included studies. Then,meta-analysis was performed using Rev Man 5.2 sot ware. Results A total of 10 case-control studies（involving 723 HCC cases and 102 controls） were included. The results of meta-analysis showed that：OPN expression was higher in HCC group than normal control group（OR=10.25,95%CI 6.13 to17.14）; and higher in imperfect capsular inifltration group than perfect capsular inifltration group（OR=2.71,95%CI 1.58 to 4.64）. However,no significant difference was found in OPN expression between isolated tumour group and multiple tumours group（OR=0.95,95%CI 0.56 to 1.62）; between high differentiation group and low differentiation group（OR=0.60,95%CI 0.36 to 1.01）; and between clinical stages I-II group and clinical stages III-IV group（OR=0.93,95%CI 0.53 to 1.63）. Conclusion Current evidence shows that OPN may take part in the whole course（occurrence and advance） of HCC in Chinese population,but the problem whether it can be used as a factor to evaluate prognosis needs to be further studied.