哺乳期妇女口服不同剂量碘油丸效果及时效观察

Effects of different iodine supplementation on lactating women

目的观察哺乳期妇女口服400 mg及200 mg碘油丸后妇女及其婴儿的碘营养状况。方法在新疆阿克苏地区两个村选择81名近半年未服用过碘油丸的哺乳期妇女,分别一次性口服400 mg或200 mg碘油丸,服药前采集妇女及其婴儿一次性随意尿样,在服药后第1至9个月每月采集妇女一次性随意尿样,第1、3、6个月每月采集婴儿一次性随意尿样,采用砷铈催化分光光度法测定尿碘。结果在干预后的9个月中,两组妇女尿碘中位数均高于干预前,差异有统计学意义(P<0.05)。除第3个月外,其他时间两组妇女尿碘中位数均为400 mg组高于200 mg组,两组之间在第7、9月差异有统计学意义(P<0.05)。干预后两组婴儿尿碘中位数均高于干预前,差异有统计学意义(P<0.05)。400 mg组婴儿尿碘中位数始终高于200 mg组,两组间仅第1个月差异有统计学意义(P<0.05)。结论两种剂量碘油丸均可提高哺乳期妇女及婴幼儿碘营养水平;400 mg碘油丸效果持续时间更长;在妇女日常食用碘盐的情况下,200 mg碘油丸对母子更加安全。

Objective To know the effects of iodine supplement of different doses on maternal and infant iodine status. Methods A total of 81 lactating women were selected from two villages of Aksu to take 400 mg or 200 mg iodized oil capsules in one time. A random urine sample was collected from both mother and infant before intervention. The urine samples were collected from women from the 1st to the 9th month after intervention, infant urine samples were collected at the 1st, 3rd, 6th month to determine the iodine concentration in urine by the arsenic cerium catalytic spectrophotometry. Results After intervention,median UIC（urinary iodine concentration） of women was higher than before. The differences between median UIC of women in the first 9 months after intervention and the maternal median UIC before intervention were respectively statistically significant in two groups（P〈0.05）. The maternal median UIC in 400 mg group were higher than that in 200 mg group in all 9 months except for the 3rd month. The differences of maternal median UIC between two groups were statistically significant at the 7th and 9th months after intervention（P0.05）. After intervention, median UIC of infants were significantly higher than before in both groups. The infant median UIC in 400 mg group were higher than that in 200 mg group in all time. The differences of infant median UIC between two groups were statistically significant in the 1st month（P0.05）. Conclusion Different doses of iodized oil capsules can sufficiently improve iodine status in lactating women and infants; The effect of 400 mg iodized oil capsule in one time may last longer; 200 mg iodized oil capsule may be safer for mothers and babies as the mothers taking iodzed salt daily.