老年高血压病患者血浆内皮素和降钙素基因相关肽水平与甲襞微循环的关系

Effect of the Level of Plasma Endothelin and Calcitonin Gene-related paptied and Nailfold Microcirculation in Aged Hypertension Patients

目的 :探讨老年原发性高血压 (EH)患者血浆内皮素 (ET)及降钙素基因相关肽 (CGRP)与甲襞微循环的关系。方法 :老年EH患者42例 ,对照组 38例 ,分别检测血浆ET、CGRP浓度及甲襞微循环。结果 :老年EH患者血浆ET及CGRP的变化与对照组相比 ,具有十分显著性意义 (P <0 .0 1) ,且ET水平与甲襞微循环损害呈正相关(r =0 .7832 ,P <0 .0 1) ;而CGRP水平与甲襞微循环损害呈负相关(r =-0 .75 2 6 ,P <0 .0 1)。结论

Objective: To investigate the relationship between plasma endothelin(ET),calcitonin gene-related peptide(CGRP)and naliflod microcirculation in aged hypertension patients.Method: To determine plasma ET?CGRP and nailfold microcirculation in 38 control group and 42 aged hypertension patients.Results: The change of plasma ET and CGRP in aged hypertension patients was significant than those in control group(P<0.01),and the level of ET was positively corelated with the injury of nailfold microcirculation(r=0.7832,P<0.01),As well as the level of VGRP was negatively correlated with the injury of nailflod microcirculation(r=-0.7526,P<0.01).Conclusion: There was a significant correlation between the level of plasma ET and VGRP and nailflod microcirculation in aged hypertension patients.