Rho激酶抑制剂在脑慢性低灌注损伤中的作用

Effect of Rho kinase inhibitor in brain of chronic cerebral hypoperfusion injury

目的：探讨Rho激酶抑制剂在脑慢性低灌注损伤中的应用效果。方法：缺血组及治疗组给予双侧颈总动脉结扎，之后治疗组加用法舒地尔，对照组未实施双侧颈总动脉结扎术及法舒地尔给药。对3组大鼠脑白质纤维密度及Rho激酶mRNA水平进行准确检测，给予统计学分析并得出结论。结果：3组大鼠经上述措施处理后，对照组脑白质纤维密度最高、治疗组其次、缺血组最低，治疗组Rho激酶mRNA水平最低、治疗组其次、缺血组最高，对比结果具有统计学意义（P＜0．05）。结论：Rho激酶可对脑白质疏松具有显著促进作用，利用Rho激酶抑制剂可显著降低脑白质纤维密度，改善脑白质疏松状态，最终获得满意的脑慢性低灌注损伤治疗效果。

Objective：To investigate the effect of Rho kinase inhibitor in brain of chronic cerebral hypoperfusion injury in.Methods：Ischemia group and treatment group was treated with bilateral common carotid artery ligation, after the treatment group plus usage effect, the control group did not implement the bilateral carotid surgery and total artery ligation fasudil administered.To accurately detect the three groups of rats brain white matter fiber density and Rho kinase mRNA levels, given statistical analysis and draw a conclusion.Re-sults：The three groups of rats after the treatment, the control group of cerebral white matter fiber density highest, lowest second treatment group, ischemia group, treatment group Rho kinase mRNA the lowest, followed by treatment group, ischemia group was the highest, com-pared the results with statistical significance （P〈0.05）.Conclusion：Rho kinase may have a positive effect on the leukoaraiosis, using Rho kinase inhibitors can significantly reduce the cerebral white matter fiber density, improve cerebral white matter loose state, eventually obtain satisfactory effect in the treatment of chronic cerebral hypoperfusion injury.