不同程度OSAHS患者的P-选择素及血液流变学水平和相关炎性因子的变化

Study of the Relationship Between the P-selectin and Blood Rheology Parameters and Inflammation Factors of OSAHS Patients

目的探讨OSAHS患者及健康人的P-选择素及血液流变学及相关炎性因子的变化。方法对我科2010年至2013年经检查诊断为OSAHS的500例患者进行分组,其中轻度患者为180例,中度为200例,重度为120例;健康对照组为60例,对上述所有研究的患者及健康人进行P-选择素及血液流变学及C反应蛋白(CRP)的检测。结果与健康组相比,OSAHS患者轻度组在P-选择素及CRP无明显差异,中度组及重度组均有差异;OSAHS患者血液流变学指标高于对照组(P<0.01)。结论 OSAHS严重程度和P-选择素及血液流变学及CRP均密切相关。

Objective To investigate the relationship between the molecular markers P -selectin and blood rheology parameters of OSAHS patients in different state and healtjy peoplehealthy peoplehealthy peoplehealthy people .Methods To compare the serum concentrations of P -selectin ,blood rheology parameters ,C-reaction protein（CRP） .in all patients there are 1 8 0 mild OSAHS patients （mild group） and 2 0 0 moderate OSAHS pa-tients （moderate group） and 120 severe OSAHS patients（severe group） and 60 normal people（normal group） . All 500 patients are diagnosed with OSAHS in the Affiliated Hospital of IMMU .Result There were no statis-tical difference between the normal group and mild group in the levels of P -selectin and CRP ,but there were significant difference between the normal group and moderate and severe group .The levels of blood rheology pa-rameters in OSAHS patients were higher than those in normal group （ P〈0 .0 1 ） .Conclusion There is close re-lationship between the severity of OSAHS P -selectin ,blood rheology parameters ,C-reaction protein（CRP） .