胰腺癌的治疗靶点

Therapeutic Targets of Pancreatic Cancer

目的总结胰腺癌(PC)的治疗靶点。方法采用文献复习的方法,对关于PC治疗靶点的文献加以综述。结果 PC是目前世界上最具挑战性的肿瘤之一,其进展性很强,预后很差,死亡率很高。PC的一个治疗难点就是它对放化疗不敏感,目前的化疗方案还不能明显改善患者的生存期。最近,一些新的治疗方案可以改善PC患者的预后,涉及到信号传导通路、免疫反应、基质反应和表观遗传变异。结论在PC的治疗中涉及多种治疗靶点。鉴于当前的治疗方案不能显著阻止PC的进展和改善其生存期,未来对于新治疗方案和临床研究的需求必将越来越强烈。

Objective To summarize the therapeutic targets of pancreatic cancer（PC）. Methods The related literatures about the therapeutic targets of PC were reviewed. Results PC was one of the most challenging tumor in worldwide, and was characterized as a highly aggressive disease with poor overall prognosis and a high mortality rate. The hallmark of PC was its poor response to radio- and chemo-therapy. Current chemotherapeutic regimens could not provide substantial survival benefit with a clear increase in overall survival. Recently, several new approaches which could significantly improve the clinical outcome of PC had been described, involving signal-transduction pathways, immune response, stroma reaction, and epigenetic changes. Conclusions Many therapeutic targets are involved in the treatment of PC. As current therapies failed to significantly improve the progression and the survival of PC, new therapeutic approaches and clinical studies are strongly required.