奥拉西坦联合脑苷肌肽治疗脑梗死的认知功能障碍的临床效果观察

A clinical observation of oxiracetam combined GM1 treating cognitive dysfunction of cerebral infarction

目的：探讨奥拉西坦联合脑苷肌肽治疗脑梗死的认知功能障碍的临床效果。方法选择2012年1月～2014年2月，我院收治的脑梗死后伴有认知功能障碍的患者100例，随机分为实验组和对照组，各50例。对照组患者单纯采用脑苷肌肽进行治疗，即5％葡萄糖或生理盐水注射液250mL＋脑苷肌肽注射液10mL静脉滴注，Qd；实验组患者采用奥拉西坦联合脑苷肌肽进行治疗，方法为：5％葡萄糖或生理盐水注射液250mL＋奥拉西坦注射液30mL静脉滴注，Qd；5％葡萄糖或生理盐水注射液250mL＋脑苷肌肽注射液10mL静脉滴注，Qd。两组治疗时间均为21d。治疗前和治疗后，分别对两组患者的简易智能状态量表（MMSE）及巴氏指数（Barthel index）进行比较。结果治疗后，两组患者的简易智能状态量表和巴氏指数较治疗前均有好转，且实验组患者改善程度明显优于对照组患者，P＜0.05，差异有统计学意义。结论奥拉西坦联合脑苷肌肽治疗脑梗死患者的认知功能障碍，能有效改善患者智能状态和日常生活自理能力，提高患者生活质量，临床应大力推广应用。

Objective To investigate the clinical effects of oxiracetam combined GM1 treatment in cognitive dysfunction of cerebral infarction. Methods 100 patients with cognitive dysfunction after cerebral infarction who were treated in our hospital from January 2012 to February 2014 were randomly divided into an experimental group and a control group, with 50 cases in each group. The control group patients only received GM1 treatment： 5% dextrose or saline injection 250mL＋GM1 injection 10mL intravenous drip, qd;The experimental group received oxiracetam joint GM1 treatment methods as follows： 5% dextrose or saline injection 250mL＋ 30mL oxiracetam intravenous injection, qd; 5% dextrose or saline injection 250mL ＋ GM1 injection 10mL intravenous drip, qd. The treatment times of the two groups both were 21 days. Simple Mental State Examination（MMSE）and Barthel index of pre-treatment and post-treatment were compared between the two groups. Results The MMSE and Barthel index of the two group with pre-treatment were better than that with post-treatment, while the extent of improvement in the experimental group than that in the control group, P 〈 0.05, the difference was statistically significant. Conclusion The treatment of oxiracetam combined GM1 in the patients with cognitive dysfunction of cerebral infarction, can effectively improve the mental state of patients and daily living skills, improve the quality of life of patients, should be vigorously promoted and used.