远程缺血预处理对移植肾缺血再灌注损伤的保护作用

Advances of remote ischemic preconditioning on renal transplatation

移植肾缺血再灌注损伤是一个不可避免的过程,不仅影响移植肾功能早期恢复,还可影响移植肾长期功能和生存率。至今尚缺乏有效措施减少缺血/再灌注引起的损伤。远程缺血预处理可通过机体内源性保护机制提高肾脏对缺血/再灌注损伤的抵抗力,有望成为防治缺血再灌注损伤的新策略。

kidney allograft ischemia-reperfusion injury （IRI） is an inevitable process, not only affects early graft function recovery, but also affects long-term graft function and survival. Up to now, there is still a lack of effective prevention and treatment strategies for reducing ischemia/reperfusion injury. Remote ischemic preconditioning can improve resistance of renal ischemia/reperfusion injury by endogenous protective mechanisms. It is expected to become the novel treatment strategies.