HIV/AIDS患者外周血CD4^+ T淋巴细胞水平与巨细胞病毒感染相关性分析

The Correlation Analysis of CD4^+ T Lymphocyte Level and Cytomegalovirus Infection in the Peripheral Blood Cells of AIDS Patients

目的:了解HIV/AIDS患者外周血CD4+T淋巴细胞水平与巨细胞病毒(CMV)感染的相关性。方法:采集300例HIV/AIDS患者外周血,进行CD4+T淋巴细胞水平和巨细胞病毒DNA检测。结果:300例HIV/AIDS患者中CMV DNA呈阳性者26例,阳性率为8.67%。CMV阳性患者中,有18例CD4+T淋巴细胞低于200个/μL,占CMV阳性者的69.23%。当CD4+T淋巴细胞计数低于200个/μL时,CMV感染率明显升高,与CD4+T淋巴细胞计数高于200个/μL时比较差异具有统计学意义(x2=18.42,P<0.05)。不同性别间CMV阳性率差异无统计学意义(x2=0.05,P=0.824)。年龄越小,CMV阳性率越高,各年龄组间差异具统计学意义(x2=7.93,P=0.042)。结论:在HIV/AIDS患者CD4+T淋巴细胞低于200个/μL时,应加强CMV监测。

Objective： To investigate the correlation analysis about the levels of CD4^＋T lymphocyte in peripheral blood and the infection status of human cytomegalovirus（ CMV） in AIDS patients. Methods： 300 AIDS-infected cases were collected for CD4^＋T lymphocytes and CMV DNA testing. Results： CMV DNA-positive patients were 26 in 300 of the AIDS-infected cases,and the positive rate was 8. 67%. There were 18 patients having fewer than 200 cells of CD4^＋cells per μL in the CMV DNA-positive cases,and it accounted for 69. 23%. When CD4 cells count was under 200 cells per μL,the mixed infection rate of CMV increased noticeably. There was significant difference between below and exceed 200 per μL（ χ^2= 18. 42,P〈0. 05）. The CMV infection rate between men and women has no statically difference（ χ^2= 0. 05,P = 0. 824）. The CMV infection rate increased as the age decrease（ χ^2= 7. 93,P = 0. 042）. Conclusion： CMV monitoring should be strengthened under the condition,if CD4 cells count was below 200 per μL in the AIDS patients.