观察不同性别胃肠道肿瘤患者化疗的不良反应

Clinical observation of adverse reactions of chemotherapy in different gender patients with gastrointestinal tract tumor

目的 观察不同性别胃肠道肿瘤患者在化疗中不良反应的特点.方法 选取行FOLFOX4化疗方案治疗的79例胃肠道肿瘤患者,其中女38例,男41例.按性别分组,观察整个化疗过程中不良反应的情况.结果 女性与男性恶心、呕吐比较差异有统计学意义（P =0.007）;腹泻（P=0.585）、口腔黏膜炎（P=0.393）、脱发（P=0.269）、神经系统毒性（P=0.212）、心脏节律改变（P=0.618）、皮疹（P=0.309）、白细胞减少（P =0.255）、血红蛋白减少（P=0.231）、血小板减少（P=0.194）、丙氨酸氨基转移酶升高（P=0.585）、肌酐升高（P=0.514）等不良反应比较差异未见统计学意义.结论 女性与男性相比,化疗中恶心、呕吐的发生率高,程度重.

Objective To investigate the characteristics of adverse reactions of chemotherapy in different gender patients with gastrointestinal tumor.Methods Seventy-nine cases of gastrointestinal cancer received FOLFOX4 chemotherapy,including 38 cases of female,41 cases of male.Grouped by gender,the adverse reactions of chemotherapy in the whole process were observed.Results Females compared with males,the difference of nausea and vomiting was statistically significant （P =0.007）;diarrhea （P =0.585）,oral mucositis （P =0.393）,alopecia （P =0.269）,nervous system toxicity （P =0.212）,heart rhythm changing （P =0.618）,rash （P =0.309）,white blood cells decreasing （P =0.255）,hemoglobin decreasing （P =0.231）,thrombocytopenia decreasing （P =0.194）,alanine aminotransferase increasing （P =0.585）,creatinine increasing （P =0.514） had no significant difference between the other adverse reactions.Conclusions Compared with men and women,the incidence of nausea,vomiting is high,and is severe.