我院436例/次地高辛血药浓度监测结果分析

Analysis of the Results of 436 Cases/Times of Digoxin Serum Concentration Monitoring

目的：为临床制订个体化给药方案提供参考。方法：采用化学发光免疫分析法对我院2013年监测的436例/次地高辛血药浓度监测结果进行统计和分析。结果：患者以男性为主,占65.36%;65岁以上患者占84.17%;血药浓度在0.5-2.0 ng/ml范围的有281例,占64.45%;血药浓度〉2.0或〈0.5 ng/ml的分别占22.25%和13.30%;女性平均血药浓度高于男性,其中血药浓度〉2.0 ng/ml的女性患者占30.46%,亦高于男性患者（17.89%）。结论：地高辛血药浓度受患者年龄、性别等因素影响。血药浓度监测结果应与患者的生理、病理情况及临床表现结合,以制订个体化给药方案。

OBJECTIVE：To analyze the results of digoxin blood concentration monitoring and provide references for clinical rational drug use. METHODS：Chemiluminescence immunoassay technique was conducted to count and analyze 436 cases/times of digoxin blood concentrations monitoring results of our hospital in 2013. RESULTS：Most patients were male,accounting for65.36%,and the patients over 65 years old accounted for 84.17%. Concentration in the range of 0.5-2.0 ng/ml accounted for64.45%,22.25% were 2.0 ng/ml and 13.30% were 0.5 ng/ml. The average drug concentration of female was higher than that of male,which female patients 2.0 ng/ml accounted for 30.46%,and higher than male patients（17.89%）. CONCLUSIONS：Digoxin blood concentration is influenced by age,gender and other factors. The individualized regimen should be developed on the basis of blood concentration monitoring,physiology,pathology and clinical manifestations.