我院190例抗菌药物致不良反应报告分析

Analysis of 190 Adverse Drug Reaction Reports Caused by Antibiotics in Our Hospital

目的:了解我院抗菌药物致药品不良反应(ADR)发生的特点及规律,促进临床安全、合理用药。方法:对我院2010-2014年上报的190例ADR报告进行回顾性统计、分析。结果:190例ADR报告中,ADR发生最多的人群为60岁以上的老年患者,占36.84%;引起ADR最多的抗菌药物为头孢菌素类,有46例,占24.21%;ADR累及器官/系统以皮肤及其附件损害最多,占56.84%。结论:临床应加强头孢菌素类抗菌药物的监测,密切观察老年患者等特殊人群的反应,谨慎选择给药途径,坚守"能口服不注射"的原则。

OBJECTIVE：To understand the characteristics and regular patterns of adverse drug reactions（ADR）caused by antibiotics in our hospital and promote safe and rational drug use in clinic. METHODS：190 ADR reports collected from our hospital from 2010 to 2014 were retrospectively analyzed. RESULTS：Among the 190 ADR reports,patients over 60 years old occupied the highest percentage（36.84%）;most of ADR were caused by cephalosporin antibiotics（46 cases,24.21%）;ADR involving organs or systems and the damages of skin and its appendages were the mainly lesions（56.84%）. CONCLUSIONS：Clinic should strengthen the ADR monitoring of cephalosporin antibiotics,closely observe the reactions of elderly patients and other special populations,carefully select the administration way and adhere to the principle that oral administration is always preferable to injection.