拉曼光谱法测定酚氨咖敏片

Study on the detection of paracetamol tablets by Raman spectrometry

以酚氨咖敏片为对象,采用i-Raman便携式光谱仪测定其拉曼光谱,对焦距偏离的容忍度、激发功率和积分时间、样品外包装材料对其拉曼光谱的影响做了研究。当工作距离偏离焦距时,其拉曼光谱信号强度明显降低,当工作距离偏离约±0.6 mm时,信号强度下降到最大值1/2。激发功率与积分时间乘积一定时,两组拉曼光谱信号强度相关系数分别为R1=0.9992和R2=0.9997。当样品与LPDE膜紧贴时,其拉曼光谱信号最佳,而当样品置于玻璃容器时,则需将样品与玻璃保持一定间隙。

This work investigated the Paracetamol tablets by i-Raman spectrometer. We have analyzed the effect of tolerance of focus length,integral time and excitation power,and the packaging material on the Raman spectra. Results demonstrated that the Raman signal intensity was reduced if the working distance was not equal to the focal length,and the signal intensity decreased to the half when the working distance deviation was about0. 6 mm. When the excitation power and integral time product was certain,the correlation coefficients obtained from the experiment were R1= 0. 9992 and R2= 0. 9997. The Raman spectra reached the best if Paracetamol tablet was packed tightly with LPDE. It was better while maintaining a certain distance if the drug was arranged in the glass container.