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miRNAs对阿尔茨海默病淀粉样蛋白产生和tau蛋白代谢作用的研究进展 被引量：2

Research Progress of MiRNAs' Effects on Amyloid-beta Production and Tau Metabolism in Alzheimer
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摘要 microRNA(miRNA)是一类长约为22 nt的小分子非编码单链RNA,由独立的非编码区RNA或蛋白编码基因的内含子转录而来,通过与其靶mRNA的3’非翻译区结合引起靶mRNA抑制发挥调节作用。近年来,miRNA在阿尔茨海默病中的角色引起广泛关注,本文从miRNA对β淀粉样蛋白和tau蛋白的影响两个方面总结了最新研究进展,以期为相关研究者提供参考。 MiRNA is a class of small,noncoding RNAs of 21 ~23 nucleotides that regulate gene expression at the postt-ranscriptional level by binding to the mRNA of protein-coding genes.In recent years,roles of miRNAs in Alzheimer＇s dis-ease pathogenesis have been paid wide attentions.This article reviews the lately progress in the effects of miRNAs on am-yloid-beta production and the microtubule-associated protein tau metabolism,which supplies a reference for further study on AD.
作者 周付涛 陈双容 谭波涛
机构地区 浙江丽水学院医学与健康学院 浙江丽水学院工程与设计学院
出处 《赣南医学院学报》 2015年第1期149-152,共4页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词 miRNA Β淀粉样蛋白 TAU蛋白 阿尔茨海默病 miRNA amyloid-beta Tau protein Alzheimer disease
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献23

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二级参考文献16

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二级引证文献20

赣南医学院学报
2015年 第1期

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