肿瘤大小对pT_(2-3)N_0M_0期胃癌根治术患者预后的影响

The prognostic value of tumor size on patients with pT_(2-3)N_0M_0 gastric cancer after operation

目的研究肿瘤大小对pT2-3N0M0期胃癌根治术患者预后的影响。方法 115例行胃癌根治术且术后病理诊断为pT2-3N0M0期的胃癌患者纳入本研究。比较不同临界值下肿瘤直径较小患者和肿瘤直径较大患者的生存率,分析肿瘤大小与其他临床病理特征的相关性。患者出院后通过电话随访、门诊记录或邮件获得患者的生存期等信息并进行生存分析。结果所有患者的肿瘤直径为0.8-12.0cm,平均直径（4.2±2.0）cm。当区分肿瘤大小的临界值定为3.6cm时,生存率的差异最显著。小直径组（53例）和大直径组（62例）在浸润深度和病理分型方面存在差异（P〈0.001）,在性别、肿瘤位置和手术方式方面无明显差异（P〉0.05）。小直径组胃癌患者的术后生存率明显高于大直径组（P〈0.05）。结论肿瘤大小是pT2-3N0M0期胃癌的独立预后因素。

Objective To explore the impact of tumor size on survival of patients with pT2-3 N0M0 gastric cancer. Methods 115 patients, underwent curative resection curative resection for gastric cancer and diagnosed with pT2-3 N0M0 gastric cancer by postoperative pathological in our hospital, were enrolled in this study. To evaluate the optimal cutoff value of umor size, the survival rates of the smaller tumor size groups and larger tumor size groups were compared. Then the correlation between tumor size and other clinicopathologic features was analyzed. The survival of patients was obtained by follow-up contact using telephone calls, the outpatient records, or mail, and the survival analysis was performed. Results The tumor size ranged from 0.8 to 12.0 cm （mean,4.2 cm） for all patients. When the threshold value was 3.6 cm, the difference of survival rates was the most evident. No significant differences were detected in sex, tumor site, and resection type between small-sized group and large-sized group. The survival rate of patients＇with small-sized group gastric cancer was significantly higher than that of patients with large-sized group. Conclusion Tumor size was an independent prognostic factor in pT2 3 N0 M0 gastric cancer.