Sox-2调节信号通路及其在肿瘤发生发展机制中作用的研究进展

Research progress of Sox-2 signaling regulation pathway and its mechanism in tumor development

Sox-2(SRY related HMG box-2)基因是最基本的干细胞基因之一,其编码的蛋白Sox-2也是维持胚胎干细胞(embryonic stem cell,EMS)及多种组织干细胞的自我更新能力和增殖能力的重要转录因子。Sox-2参与复杂的细胞信号转导通路网络,调控细胞的生物学行为;同时,Sox-2的表达也在转录、翻译及翻译后水平受到不同因子的调节。近年来越来越多的研究表明,在肿瘤的发生、生长、增殖及侵袭转移中,Sox-2也有重要的作用,它在多种类型肿瘤中参与肿瘤细胞的不同生物学行为。文中综述了Sox-2在调节组织发育及肿瘤发生中的作用,并阐述Sox-2所参与的复杂信号转导通路网络,及目前所发现在肿瘤诊断和治疗方面的临床价值。

Sox-2（SRY related HMG box-2）is an essential embryonic stem cell gene and a necessary transcription factor for maintaining the proliferation and self-renewal capability of embryonic stem cell .Sox-2 is involved in complex cell signal transduction pathway network and adjusting biological behavior of cells .Expression of Sox-2 is adjusted by different factors in transduction , transla-tion and post-translation levels .In recent years , increasing evidences indicate Sox-2 has an important role in tumor development , growth, proliferation, and metastasis, which is involved in various biological behavior of tumor cells in many types of tumors .This pa-per reviews the role of Sox-2 in adjusting tissue and tumor development and complex cell signal transduction pathway network of Sox -2 and clinical values of Sox-2 in tumor diagnosis and treatment until now .