应用OCT观察羟氯喹对视网膜的早期影响

Effect of hydroxychloroquine treatment on the retinal nerve fiber layer

目的 通过OCT评估羟氯喹对视网膜神经纤维层（RNFL）的损害.方法 回顾性病例研究.对30例使用羟氯喹治疗少于5年并且没有发生眼底改变的患者和30例健康者进行视力、视野、眼底和OCT的检查.结果 治疗期间视力、眼底和视野的检查均无异常.OCT发现服用羟氯喹组患者的内层黄斑区视网膜厚度内外圈各象限均有显著降低.结论 OCT能观察到羟氯喹对视网膜的早期损伤.

Objective To evaluate the damage to retinal function in patients receiving hydroxychloroquine （HCQ） by observing the changes in the retinal nerve fiber layer （RNFL）.Methods A retrospective study was performed on 30 patients with rheumatoid arthritis who were treated with HCQ therapy and 30 healthy people.Visual acuity,visual field and fundus examinations as well as optical coherence tomography （OCT） were compared between the two groups.Results Visual acuity,visual field and fundus examinations were normal.Decreases were noted with OCT.Conclusion OCT can detect early retinal toxicity due to hydroxychloroquine.