角巩膜胶原交联中核黄素渗透性的研究进展

Research progress in riboflavin permeability in corneal and scleral collagen cross-linking

紫外线刖蓝光-核黄素胶原交联法能显著提高角巩膜组织胶原纤维的机械强度,核黄素在胶原交联中既是光敏剂,也是保护剂,其在眼组织内的含量直接影响着胶原交联的效果与眼组织的安全.而核黄素在角巩膜内的含量受多种因素影响,并且需要合理的检测方法来判断,现将对以上两方面进行阐述.

Ultraviolet A and blue lights in riboflavin cross-linking are effective approaches to increase the mechanical and biochemical rigidity of collagen fibers.The effect of cross-linking and the safety of the eye are affected by riboflavin,which acts as a photosensitizer and protective agent.The riboflavin content in the comea and sclera relates to many factors and needs to be detected by reasonable methods.This article focuses on the two methods mentioned above.