口腔溃疡豚鼠血清中谷胱甘肽过氧化物酶活性的研究

Study on Glutathione Peroxidase Activity in Serum of the Oral Ulcer Guinea Pig

目的：研究口腔溃疡豚鼠血清中谷胱甘肽过氧化物酶（GSH-PX）的活性。方法：用90%苯酚溶液灼烧豚鼠左侧面颊，造成口腔溃疡模型，观察豚鼠口腔溃疡模型的溃疡面积、溃疡程度及溃疡组织病理变化，测定血清中GSH-PX活性。结果：用苯酚溶液造豚鼠口腔溃疡模型成功，d1～d5，模型组与空白组相比，口腔溃疡程度显著，血清中GSH-PX活性显著降低（P＜0.01）。口腔溃疡豚鼠随着时间的变化溃疡面积逐渐缩小，血清中GSH-PX活性逐渐增强。结论：血清中GSH-PX对口腔溃疡的自愈有促进作用。

Objective：To investigate the activity of glutathione peroxidase （GSH-PX）in serum of the oral ulcer guinea pig. Methods：Guinea pig model with oral ulcer was induced by burning the left cheek with 90% phenol solution. The area of ulcer, the degree of ulcer and the changes of organization pathological were observed in guinea pig model of oral ulcer. The activity of GSH-PX was determined in serum. Results：The phenol-induced guinea pig has been established successfully.1～5d, compared with blank control group, the degree of ulcer in the model group was obvious, the activity of GSH-PX was decreased significantly（P〈0.01）.Along with the changes of time,the area of ulcer was decreased gradually, the activity of GSH-PX in serum was increased gradually. Conclusion：The GSH-PX in serum has a promoting role in oral ulcer healing.