溴隐亭不同给药途径治疗女性高泌乳素血症临床分析

Clinical analysis of different routes of administration of bromocriptine in treating women with hyperprolactinemia

目的观察溴隐亭不同给药途径治疗女性高泌乳素血症的临床疗效。方法选取我院2010年1月~2013年12月于我院妇科就诊的高泌乳素血症患者128例,随机分为试验组（63例）和对照组（65例）,试验组予阴道放置溴隐亭治疗,对照组口服溴隐亭,3个月后进行疗效对比。结果两组治疗不同时期血清催乳素（PRL）水平均与治疗前相比,差异有统计学意义（P〈0.05）。试验组治疗后0.5个月、1个月、2个月、3个月PRL水平与对照组比较差异无统计学意义（P〉0.05）,试验组治疗后月经失调、闭经、泌乳、多毛等临床症状发生率与对照组比较差异无统计学意义（P〉0.05）。结论采用溴隐亭治疗女性高泌乳素血症,不同的给药途径对疾病的疗效无明显差异,因此可根据患者的个体差异制定个性化治疗方案,避免不良反应发生,缩短疗程。

Objective To observe the clinical efficacy of different routes of administration of bromocriptine treatment of women with hyperprolactinemia. Methods 128 cases with hyperprolactinemia were selected from Jan 2010 to Dec 2013 in our hospital, they were randomly divided into the experimental group（n=63） and the control group（n=65）, the experimental group was given vaginal bromocriptine, the control group was given oral bromocriptine method, the efficacy of three months after treatment were compared. Results Two groups after treatment compared with before treatment, the difference was statistically significant in PRL （P〈0.05）, 0.5 months after treatment, a month, two months, three months after treatment, the experimental group compared with control group, PRL levels after treatment differences were not significant （P〉0.05）, the experimental group of clinical symptoms after treatment of menstrual disorders, amenorrhea, lactation, hirsntism proportional compared with the control group was no significant difference （P〉0.05）. Conclusion Different routes of administration of bromocriptine had no significant difference in the efficacy of the disease, it can be formulated according to individual differences in the patients＇ individualized treatment plan, and avoid adverse reactions occurring and shorten the course.