参松养心胶囊联合琥珀酸美托洛尔缓释片治疗室性早搏的疗效观察

Effect observation of Shensongyangxin capsules combined with metoprolol succinate extended release tablets in the treatment of premature ventricular contractions

目的观察参松养心胶囊联合琥珀酸美托洛尔缓释片治疗室性早搏的临床疗效。方法选取2012年4月-2013年9月收治的室性早搏患者100例,随机分为治疗组与对照组各50例。2组患者在常规治疗原发病的基础上,均停用所服用的抗心律失常药物7d以上,对照组给予琥珀酸美托洛尔缓释片口服;治疗组在对照组的基础上加服参松养心胶囊4粒/次,3次/d;2组均治疗1个疗程(4周为1个疗程)。观察其疗效及不良反应。结果治疗组总有效率92.0%明显高于对照组的78.0%,差异有统计学意义(P<0.05);治疗组动态心电图症状改善效果总有效率84.0%明显高于对照组的62.0%,差异有统计学意义(P<0.05)。结论参松养心胶囊联合琥珀酸美托洛尔缓释片剂治疗室性期前收缩可提高疗效且安全性较好,值得在临床推广使用。

Objective To observe the clinical efficacy of Shensongyangxin capsules combined with metoprolol succi -nate extended release tablets in the treatment of premature ventricular contractions .Methods From April 2012 to September 2013 ,100 cases of patients with premature ventricular contractions were randomly divided into treatment group and control group,each of 50 cases.On the basis of conventional treatment of primary disease ,both groups were discontinued taking anti ar-rhythmic drugs more than 7d.The control group received metoprolol succinate sustained-release tablets for treatment;on the ba-sis of the control group,the treatment group was added with Shensongyangxin capsules ,4 capsules/time,3 times/d.The 2 groups were treated for 1 course （4 weeks for a course）.The efficacy and adverse reactions of 2 groups were observed.Results The total effective rate of the treatment group was 92.0%,which was higher than 78.0% of the control group,the difference was statistically significant （P〈0.05）.The total efficiency of dynamic electrocardiogram symptoms improvement of the treat -ment group was 84.0%,which was higher than 62.0% of the control group,the difference was statistically significant （P〈0.05 ） .Conclusion The method that Shensongyangxin capsules combined with metoprolol succinate extended release tablets can improve curative effect in the treatment of premature ventricular contractions ,with good safety ,which is worthy of populari-zation and application .