盐酸羟考酮用于老年患者术后镇痛的疗效观察

The effect of oxycodone hydrochloride used in elderly patients for postoperative analgesia

目的观察盐酸羟考酮用于老年患者术后镇痛的效果及安全性,为临床用药提供依据。方法选取医院收治入院的老年手术患者80例为研究资料,将其随机分为2组(A组和B组)各40例,患者经全麻诱导、气管插管后行机械通气下完成手术。A组给予盐酸羟考酮30mg+托烷司琼10mg,B组给予盐酸羟考酮30mg+氟比洛芬酯150mg+托烷司琼10mg;记录观察苏醒后(T0)、2h(T1)、4h(T2)、12h(T3)、24h(T4)的VAS评分和Ramsay镇静评分及各时点PCA泵按压次数、不良反应发生率。结果 A组和B组都可以到达较好的术后镇痛效果。与B组比较,T0、T1、T2时A组VAS评分明显升高(P<0.05)。B组Ramsay镇静评分明显升高(P<0.05)。A组PCA实际、有效按压次数明显增多(P<0.05)。差异均有统计学意义。结论盐酸羟考酮用于老年患者术后镇痛是安全有效的,不良反应少,适合临床应用。

Objective To observe the effect and safety of oxycodone hydrochloride used in elderly patients for postop -erative analgesia ,in order to provide a basis for clinical medicine .Methods 80 research data of elderly surgical patients were selected in our hospital .All the patients were randomly divided into 2 groups （ group A and group B ） .The operation was com-pleted under mechanical ventilation after general anesthesia induction and endotracheal intubation .According to different group give different patient controlled intravenous analgesia （ PCIA） drug.Group A：oxycodone hydrochloride 30mg ＋tropisetron 10mg.Group B：oxycodone hydrochloride 30mg＋flurbiprofen 150mg＋tropisetron 10mg.VAS and Ramsay score,pressure times of PCA pump,and the incidence of adverse events were recorded in （T0）,2h（T1）,4h（T2）,12h（T3）,24h（T4） after recover-y.Results Group A and group B can achieve effective analgesia .Compared with group B,the VAS in group A was signifi-cantly higher at T0,T1,T2（P〈0.05）.The Ramsay score in group B was significantly increased （P〈0.05）.The real and ef-fective press times of PCA pump was significantly increased in group A ,the difference was statistically significant （ P〈0.05 ） . Conclusion The oxycodone hydrochloride used in elderly patients for postoperative analgesia is safe ,effective,with fewer ad-verse events.So it is suitable for clinical use .