狼疮性肾炎并发社区获得性肺炎患者的抗感染用药监护

Medication Monitoring of Anti-infection Drugs in a Patient with Lupus Nephritis Complicated with Community Acquired Pneumonia

目的:分析临床药师参与狼疮性肾炎并发社区获得性肺炎患者抗感染用药监护。方法:对1例狼疮性肾炎并发社区获得性肺炎(重症)患者进行全程药学监护,协助医师制定抗感染药物治疗方案,并随病情变化作修正或调整。结果:莫西沙星和哌拉西林钠/他唑巴坦钠的联合用药,使患者的肺部感染得到及时有效控制,避免了潜在狼疮性肾炎复发或加重的危险。结论:特殊人群抗菌药物的选择,不仅要考虑抗菌谱、抗菌活性,还应结合患者的个体特征和药动学特性来做综合选择,可提高患者用药的安全性和有效性。

Objective： To explore the value of clinical pharmacists in the anti-infection practice for a patient with lupus nephritis complicated with community-acquired pneumonia（ severe）. Methods： Clinical pharmacists carried out medication monitoring in the entire treatment process of a patient with lupus nephritis complicated with community-acquired pneumonia（ severe） in the clinical front line. Depending on the pharmaceutical knowledge,clinical pharmacists assisted physicians to make out the optimal medication and adjusted the medication according to the patient＇s conditions. Results： Moxifloxacin and piperacillin sodium / tazobactam sodium could effectively control the severe pulmonary infection of the patient with lupus nephritis and avoid the potential risk of recurrence or aggravation of lupus nephritis. Conclusion： The choice of antimicrobial agents for the special populations should consider not only the antibacterial spectrum and antibacterial activity,but also the individual characteristics of patients and pharmacokinetics of drugs in order to improve the safety and effectiveness of medication.