异常黏液证大鼠模型与内分泌-免疫功能的关系

Relationship between abnormal balgam syndrome rat model and endocrine-immune function

目的:研究异常黏液质证大鼠模型内分泌-免疫功能有关指标的变化,并探讨异常黏液质证与内分泌、免疫功能的内在联系。方法:采用ELISA方法检测异常黏液质证大鼠血清促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)和皮质醇(CORT)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)的含量变化。结果:异常黏液质证模型组大鼠的血清ACTH、CRH、IL-1β、IL-6、IL-10的含量显著升高,与正常大鼠比较,差异有统计学意义(P<0.05)。结论:异常黏液质证模型大鼠的下丘脑-垂体-肾上腺轴(HPA轴)及免疫功能处于应激激活及紊乱并存状态。

Objective： To explore the intrinsical link between abnormal balgam syndrome and endocrine-immune network by observation of the relative indexes of endocrine-immune function in rat with abnormal balgam syndrome.Methods： ELISA method was used to detect the contents of endocrine-immune related indexes including corticortopin-releasing-hormone（CRH）,adrenocotropic hormone（ACTH）,cortisol（CORT）,interleukin-1β（IL-lβ）,interl eukin-6（IL-6）,and interleukin-10（IL-10） levels in serum.Results： Compared with the normal control group,the contents of ACTH,CRH,IL-1β,IL-6 and IL-10 in serum of abnormal balgam syndrome model group were all increased（P〈0.05）.Conclusion： The HPAA axis and immune function of abnormol balgam syndrome rat model are in stress-activated and disorder state.