基于数据挖掘的国医大师颜正华含丹参处方用药规律研究

Analysis on the rule of herb using in TCM master YAN Zheng-hua's prescriptions contained Radix Salviae Miltiorrhizae based on data mining

目的:探讨国医大师颜正华教授处方用药规律。方法:在收集处方基础上,基于中医传承辅助系统构建数据库,进而使用关联规则apriori算法等数据挖掘方法,分析颜正华教授含丹参处方中常用单味药物频次、药物组合频次、关联规则与核心药物组合等。结果:含丹参处方常用于治疗眩晕、胸痹、不寐等病症,高频次药物组合包括"丹参,赤芍"、"丹参,炒酸枣仁"、"丹参,首乌藤"、"丹参,白芍"等,置信度为1的关联规则包括"牛膝->丹参"、"白芍->丹参"、"赤芍->丹参"等。结论:颜正华教授含丹参处方所用药物多具补血活血、安神之功效,用药较为集中,组方法度清晰。

Objective： To investigate the rule of herb using in TCM master YAN Zheng-hua＇s prescriptions.Methods： Database was established based on prescription collection and auxiliary system of inheritance of TCM.The frequency of single drug,frequency of drug combination,association rules and core drug combination of YAN Zheng-hua＇s prescriptions contained Radix Salviae Miltiorrhizae were analyzed with apriori arithmetic.Results： Prescriptions contained Radix Salviae Miltiorrhizae were used to treat with dizziness,qi blockage in the chest,insomnia and so on.The high frequency of drug combination included ‘Radix Salviae Miltiorrhizae,Radix Paeoniae Rubra＇,‘Radix Salviae Miltiorrhizae,Semen Ziziphi Spinosae＇,‘Radix Salviae Miltiorrhizae,Caulis Polygoni Multiflori＇ and ‘Radix Salviae Miltiorrhizae,Radix Paeoniae Alba＇.The association rules with 100% confidence were ‘Radix Achyranthis Bidentatae-Radix Salviae Miltiorrhiza＇,‘Radix Paeoniae Alba- Radix Salviae Miltiorrhiza＇,‘Radix Paeoniae Rubra-〉Radix Salviae Miltiorrhiza＇ and so on.Conclusion： Professor YAN＇s prescriptions contained Radix Salviae Miltiorrhiza had the effect of replenishing blood,activating blood circulation and tranquillization,and the thoughts of proprietary composition was clear and drug was used concentrated.