摘要
目的观察地西泮对兔定量药物脑电图(QPEEG)δ频段功率百分比的影响及其与苯二氮受体的关系。方法 36只家兔随机分为6组(n=6),均静脉注射。空白组用0.9%氯化钠1 m L·kg-1,3个剂量地西泮组:0.12,0.25,0.50 mg·kg-1地西泮,氟马西尼组用氟马西尼0.1 mg·kg-1,合用组先注射0.1 mg·kg-1氟马西尼5min后,再注射0.5 mg·kg-1地西泮。用数字脑电地形图仪分别计算给药前及给药后各时间点兔各脑区QPEEGδ频段功率百分比。结果与给药前比较,0.25,0.50 mg·kg-1地西泮组各脑区δ频段功率百分比在0.5~30.0 min增加,且与地西泮剂量呈正相关;合用组的δ频段功率百分比明显低于同时点的0.50mg·kg-1地西泮组。结论地西泮以剂量依赖方式增加兔QPEEGδ频段功率百分比且由苯二氮受体介导,提示δ频段可能成为反映镇静催眠程度的指标。
Objective To observe the effects of diazepam on the percen-tage of δ -band power of quantitative pharmaco -electroencephalogram ( QPEEG ) in rabbits and the relation with benzodiazepine receptor.Methods Thirty-six healthy rabbits were randomly divided into 6 groups (each n=6),where rabbits in each group were intravenously injected with 1 mL· kg-1 0.9%NaCl (blank group), 0.12 mg· kg-1 , 0.25 mg· kg-1 or 0.50 mg· kg-1 diazepam groups, 0.1 mg· kg-1 flumazenil group and 0.1 mg· kg-1 flumazenil +0.5 mg· kg-1 diazepam ( combined group ).Then a digital EEG system was adopted to record the changes of QPEEG in eight encepha-lic regions before and after injection at each time point.Results The per-centage of δband power in eight encephalic regions of 0.25, 0.50 mg· kg-1 diazepam groups are noted increase within 0.5 to 30 min.The change of the percentage of δ band power has a positive correlation with diazepam dose.Compared with the 0.5 mg· kg-1 diazepam group,the percentage of δ-band power in combined group was lower at same time point.Conclusion Diazepam increases the percentage ofδ-band power of QPEEG in the way of dose dependence in rabbits.It indicates that benzodiazepine receptor mediates the effect of diazepam and the percentage of δ-band power may become an index that reflects the degree of sedation and hypnosis.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第7期540-543,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(30872432
30471657
39970715)
江苏省社会发展科技计划基金资助项目(BS 200054)
徐州医学院药学院研究生科研创新计划基金资助项目(2010YKYCX011)
关键词
地西泮
氟马西尼
定量药物脑电图
镇静催眠程度
Δ频段
diazepam
flumazenil
quantitative pharmaco -electroencephalogram
degree of sedation and hypnosis
δ-band