肥胖2型糖尿病患者血清铁蛋白水平及相关因素分析

The changes of serum ferritin and homocysteine and their associated factors in obese type 2 diabetes mellitus

目的观察肥胖T2DM患者血清铁蛋白(SF)、同型半胱氨酸(Hcy)水平的变化及其相关因素。方法选取新诊断T2DM患者62例和体检者38名,根据BMI分为T2DM合并肥胖(T2DM+Ob)组26例、单纯T2DM组36例、单纯肥胖(Ob)组18例及正常对照(NC)组20名,比较各组血清SF、Hcy、FPG、FIns、TC、TG、FFA及胰岛素抵抗指数(HOMA-IR)水平,并分析其相关性。结果 SF和Hcy水平在NC组、Ob组、T2DM+Ob组和Ob组逐渐升高[SF:(168.70±20.00)vs(202.11±23.48)vs(236.08±32.38)vs(286.19±34.92)ng/ml;Hcy:(6.99±1.37)vs(8.61±1.98)vs(9.97±1.30)vs(13.64±1.92)μmol/L,P<0.05]。多元逐步回归分析显示,T2DM患者SF与BMI、FFA呈正相关(P<0.05)。结论 T2DM患者SF和Hcy水平高于非糖尿病人群,其中,肥胖者SF和Hcy高于非肥胖者,提示SF和Hcy可能与肥胖、糖尿病相关。

Objective To investigate the changes of serum ferritin（SF） and homocysteine （Hcy） and their associated factors in obese type 2 diabetes mellitus. Methods A total of 62 newly diagnosed type 2 diabetes and 38 controls were enrolled in this study. All the participants were divided into four groups ：obese T2DM group （T2DM＋ Ob ,n=26） ,T2DM without obesity group （T2DM ,n=36） ,obese group （Ob ,n=18） and control group（NC ,n=20）.Serum SF ,Hcy ,FPG ,TC ,TG ,FFA ,homeostatic model assessment for insulin resistance （HOMA‐IR） and their association were tested in all the groups. Results Serum levels of SF and Hcy were gradually increased in NC group ,Ob group ,T2DM＋ Ob group and Ob group[SF：（168.70 ± 20.00） vs （202.11 ± 23.48） vs （236.08 ± 32.38） vs （286.19 ± 34.92）ng/ml;Hcy ：（6.99 ± 1.37） vs （8.61 ± 1.98） vs （9.97 ± 1.30） vs （13.64 ± 1.92）μmol/L ,P〈0.05]. SF was positively correlated with BMI ,FFA in T2DM patients by the muti‐stepwise regression analysis（P〈 0.05）.Conclusion Serum levels of SF and Hcy were increased in T2DM patients. Serum SF and Hcy may be involved in the process of obesity and T2DM.