肝动脉热化疗栓塞治疗原发性肝癌疗效观察

Thermochemoembolization for primary hepatocellular caicinoma-A middle and long period clinical observation

目的:评价热化疗栓塞对原发性肝癌的中长期疗效。方法:回顾性分析1994年11月至2012年2月172例原发性肝癌行热化疗栓塞治疗患者的临床资料,应用Seldinger技术,经股动脉穿刺置管,通过肝动脉导管将微导管超选择置入肿瘤供血动脉,以碘油20ml与顺铂100mg或丝裂霉素8mg的110℃混悬液行热化疗栓塞。以门诊及电话方式随访收集资料。通过影像学检查观察肿瘤大小变化,用寿命表法计算患者累积生存率。结果:1-10年累积生存率分别为52.33%、34.88%、21.51%、12.21%、7.56%、1.74%、1.74%、1.16%、1.16%、1.16%。治疗前后有CT、B超或DSA等影像学资料对比的患者160例,完全缓解(CR)2例(1.25%),部分缓解(PR)49例(30.63%),稳定(SD)78例(48.75%),进展(PD)31例(19.38%);有效率(CR+PR)31.88%,肿瘤控制率(CR+PR+SD)80.63%。结论:热化疗栓塞是原发性肝癌的有效治疗手段。

Objective:To evaluate the long term results of thermochemoembolization for hepatocellular carcinoma. Methods:All of 172 cases of primary hepatocellular carcinoma were treated with thermochemoembolization.The re-sults were followed up and analyzed according to imagiology and the survival time.Results:Forall patients,the surviv-al rates from 1 to 10 years were 52.33%,34.88%,21.51%,12.21%,7.56%,1.74%,1.74%,1.16%,1.16%,1.16%respectively.The overall response rate was 3 1 .88%,including 2 complete remission(CR),49 partial remission(PR). The tumor control rate(CR+PR+SD)was 80.63%.Conclusion:Thermochemoembolization was an effective thera-peutic mean for primary hepatocellular carcinoma.