摘要
目的:观察舍曲林联合小剂量阿立哌唑口腔崩解片治疗难治性抑郁症患者的疗效。方法:将76难治性抑郁症患者随机分成治疗组40例、对照组36例。治疗组患者用舍曲林联合小剂量阿立哌唑口腔崩解片治疗,对照组患者单用舍曲林治疗,观察8周。分别于治疗前及治疗后第1、2、4、8周末采用HAMD(汉密尔顿抑郁量表)评定疗效,用TESS(副反应量表)观察不良反应。结果:经8周治疗后,两组患者经Ridit评分,差异有统计学意义(P〈0.05)。HAMD评分第1、2、4周末两组患者有显著性差异(P〈0.01~0.05),两组患者的不良反应均较低。结论:舍曲林联合小剂量阿立哌唑口腔崩解片治疗难治性抑郁症患者的疗效肯定,不良反应轻微。
Objective:To observe clinical effects of Sertraline combined with small-dose Aripiprazole orally disintegrating tab-lets in treatment of treatment-resistant depression. Methods:76 patients with treatment-resistant depression were randomly assigned into research group (40 patients) and control group (36 patients). Research group received Sertraline combine with small-dose Aripi-prazole ODT for 8 weeks and control group accepted Sertraline alone for 8 weeks. The efficacy and adverse reactions before the treat-ment and at the end of 1st, 2nd, 4th and 8th week of treatment were measured by Hamilton depression scale (HAMD) and treatment emergent symptom scale ( TESS) . Results:There were significant differences of HAMD scores between the two groups at the end of 1st, 2nd, and 4th week of the treatment (P<0. 01~0. 05), and there were also statistical differences of Ridit scores between the two groups patients at the end of 8th week of treatment. The two groups both had fewer adverse reactions. Conclusions: Sertraline com-bined with small-dose Aripiprazole ODT has a certain efficacy in the treatment of treatment-resistant depression with mild adverse re-actions.
出处
《中国民康医学》
2015年第8期16-17,共2页
Medical Journal of Chinese People’s Health
关键词
舍曲林
阿立哌唑口腔崩解片
难治性抑郁症
Sertraline
Aripiprazole orally disintegrating tablets
Treatment-resistant depression