颅内动脉瘤破裂的临床特征及危险因素分析

Clinical characteristic and risk factors of intracranial aneurysm rupture

目的探讨未破裂颅内动脉瘤发生破裂的临床特点及危险因素。方法将124例颅内动脉瘤患者分为破裂组96例和未破裂组28例,对其临床及随访资料进行回顾性分析。采用χ2检验及logistic逐步回归模型分析颅内动脉瘤发生破裂的相关危险因素。结果颅内动脉瘤破裂出血的首发症状多为头痛(84.38%)和头晕(81.25%)。饮酒(P=0.036)、高血压(P=0.041)、疲劳(P=0.019)、情绪波动(P=0.016)、吸烟(P=0.014)、动脉瘤部位(P=0.009)和动脉瘤大小(P=0.032)在破裂组和未破裂组比较差异均有统计学意义,并经多因素logistic逐步回归分析证明,其均是动脉瘤破裂的危险因素。结论颅内动脉瘤破裂首发症状以头痛、头晕为主。饮酒、高血压、疲劳、情绪波动、吸烟、动脉瘤部位及动脉瘤大小等是动脉瘤破裂的危险因素。

Objective To investigate the clinical characteristic and risk factors of intracranial aneurysm（ IA） rupture.Methods A total of 124 patients suffered IA including rupture group（ n = 96） and unruptured group（ n = 28） were selected and their clinical and follow up data was analyzed respectively. Chisquare test and logistic stepwise regression model were used to analyze the risk factors for IA rupture. Results The first symptom of IA rupture was headache（ 84. 38%） and dizzy（81. 25%）. Alcohol（P = 0. 036）,hypertension（P = 0. 041）,tired（P = 0. 019）,mood fluctuation（ P = 0. 016）,cigarette smoking（ P = 0. 014）,the position of IA（ P = 0. 009） and the size of IA（ P = 0. 032） were associated significantly with IA rupture and they were the risk factors for IA rupture which were proved by logistic stepwise regression model. Conclusion The main first symptom of IA rupture is headache and dizzy. Alcohol,hypertension,tired,mood fluctuation,cigarette smoking,the position of IA and the size of IA are the risk factors of IA rupture.