维生素D及其受体在胰腺癌中的研究进展

Research Progress of Vitamin D and Vitamin D Receptor in Pancreatic Cancer

胰腺癌是全球最致命的恶性肿瘤之一,其发病率接近死亡率。绝大多数胰腺癌患者在确诊时已属晚期,失去手术治疗机会,而放、化疗对胰腺癌的疗效并不确切,目前分子靶向治疗已成为治疗恶性肿瘤的重要手段,因此,亟需研发新的治疗靶点。大量体内外实验证明,维生素D可通过与其受体(VDR)结合发挥抗肿瘤作用。维生素D通路作为治疗胰腺癌的新靶点,已成为目前研究的一个热点。全文主要就维生素D及其受体的结构、功能、抗肿瘤作用机制以及在胰腺癌中的研究进展作一综述。

Pancreatic cancer is one of the most lethal malignancies worldwide,its incidence is still nearly equal to its mortality. The vast majorities of patients with pancreatic cancer are diagnosed in the late stage and lose the chance of surgical therapy. However,there is no known effective radiotherapy and chemotherapy to treat pancreatic cancer,and now,molecular targeted therapy has become an important treatment for patients with malignancy. Therefore,new therapeutic targets are urgently needed. Vitamin D can exert antitumor actions through binding to vitamin D receptor（VDR） in vitro and in vivo models. Vitamin D pathway,as a new target for the treatment of pancreatic cancer,has been under active study in recent years. The structure,functions and mechanism of anti-tumor action of vitamin D and VDR,and the recent progress of vitamin D and VDR in pancreatic cancer were discussed in this paper.