阿苯达唑治疗肝泡球蚴病80例临床观察

EIGHTY CASES OF ALVEOLAR HYDATID DISEASE TREATED WITH ALBEISDAZOLE

从1985年起,用口服阿苯达唑治疗泡球蚴病80例均获显著近期疗效。甲组72例,口服8-10mg/kg·d×30,间隔10d,再服另一疗程,连服3-12个月;乙组8例,15.6—20mg/kg·d×14,每疗程间隔10d,连服3—6个月。经3—5年随访,一般症状均有好转,体重增加2—9.5kg,占77.8(45/58)能自理生活或参加轻体力劳动。服药2—3个月黄疸消失,黄疸指数恢复正常的占80％(20/25);肝功有明显改善的占73％(48/66);絮浊度化验约50％转为正常;复查原来肿大的肝脏:剑突下缩小1-6cm占50％(40例),右肋缘下缩小1—3cm占42.5％(34例),左肋缘下缩小占17.5％(14例)。B超复查原左右扩张的胆管及肿块缩小的占23.7％,中央液化或液化范围较服药前增大的占42.5％;病灶内钙化阴影较药前明显增多。

Alveolar hydatid disease occurs frequently in Xiji County of Ningxia. 80 cases of the disease were treated orally with albendazole from 1985 to 1988 and the short-term results proved satisfactory.The treatment consisted of two groups. Group Ⅰ included 72 cases which were orally given 8-10 mg/kg · d of albendazole 2 to 3 times a day after each meal for 30 days and then stop taking the medicine for 10 days as one trealment course. The treatment continued 3-12 months comprising about 24 courses were given with the highest dosage of 412g. Group Ⅱ included 8 cases who were given 15.6-20mg/kg · d of the medicine for 14 days (one course) and every two weeks with a 10 days interval. The treatment of group Ⅱ continued 3-6 months which totalled 19-24 courses with the highest dosage of 270g. All the treated patients tolerate well except that a few of them felt giddy and had diarrhoea which disappeared after the withdrawal of medicine.Through 3-5 years, follow-up observation, it was found that the gener alsymptoms of the treated partients improved and their body weight increased by 2-9.5kg., some of them could take part in light physical labour. The jaundice index in 80% of them returned to normal. SGPT in 86.4% decreased to within normal range. The enlarged livers in half of the patients decreased by 1-6cm. 23.7% of the patients were reexamined by B ultrasound scanning which revealed that their enlarged liver reduced in size while the liquifaction area and the shadows of calcification in the livers in 42.5% patients increased obviously.