新辅助化疗治疗晚期子宫内膜癌的效果观察

Observation on the effect of neoadjuvant chemotherapy in the treatment of advanced endometrial cancer

目的探讨新辅助化疗治疗晚期子宫内膜癌的临床效果。方法 80例晚期子宫内膜癌患者随机分为观察组和对照组,各40例。观察组患者给予顺铂+紫杉醇方案的新辅助化疗4个疗程;对照组患者手术后进行相同方案的化疗。结果观察组的化疗总有效率为75.0%,明显高于对照组的52.5%,差异有统计学意义(P<0.05)。观察组的胃肠道反应和骨髓抑制的发生率,以及毒副作用的总发生率,均显著低于对照组(P<0.05)。结论与常规术后化疗比较,新辅助化疗治疗晚期子宫内膜癌的近期疗效显著,且毒副作用发生率较低,但仍需进行大样本的研究进一步明确其价值。

Objective This paper as to investigate the clinical effect of neoadjuvant chemotherapy in the treatmentofadvancedendometrialcancer.Methods 80patientswithadvancedendometrialcancerwererandomly divided into observation group and control group, 40 in each group.Patients in observation group were treated with cisplatin and paclitaxel regimen for 4 courses during preoperative period and patients in control group were treated with same regimen during postoperative period.Results The total short-term effective rate of observation group was 75.0%, which was significantly higher than 52.5% in control group, the difference was statistically significant （P〈0.05）.The incidence of gastrointestinal reaction, myelo suppression and the total rate of toxicity in observation group was significantly lower than those of control group （P〈0.05）.Conclusions Compared with conventional postoperative chemotherapy, short-term effect of neoadjuvant chemotherapy is significant higher and has lower toxicity in treating advanced endometrial carcinoma, but further studies with larger sample size are still needed to define its value.