老年哮喘急性发作期IL-4、IL-18水平及临床意义

Clinical significance of the level of IL-4 and IL-18 in the acute phase of elder patients with asthma

目的：探讨老年支气管哮喘患者急性发作期外周血白细胞介素4（IL－4）和血白细胞介素18（IL－18）水平及其临床意义。方法2012年7月至2014年10月，急性发作期老年哮喘患者82例（哮喘组），男54例，女28例，年龄60-83岁，平均（71．5±8．08）岁；对所有患者入院急性发作期和治疗后缓解的人血清中IL－4、IL－18水平采用ELISA法检测。结果急性发作期老年哮喘患者的血清IL－4明显高于缓解期（P＜0．05），IL－18明显高于缓解期（P＜0．05）。结论 IL－4、IL－18均参与了老年支气管哮喘急性发作期的发病机制，在Th1／Th2细胞因子网络失衡的发病机制中起重要的调节作用。

Objective We aimed to investigate the clinical significance of the level of interleukin-4（ IL-4）andinterleukin-18（IL-18）intheacutephaseofelderpatientswithasthma.Methods 82elderpatients who suffered from asthma in the acute phase were enrolled in this study, 54 male and 28 female, they aged from 60 to 83 years old, 71.5 ±8.08 years old on average.These patients were hospitalized in our hospital during July 2012 and November 2014.The level of IL-4 and IL-18 were detected by Enzyme-linked immunosorbent assay （ ELISA） .Results The concentration of IL-4 and IL-8 in the acute phase was significantly higher than that in the remission phase （P〈0.05）.Conclusions The levels of IL-4 and IL-8 play an important role in allergic reaction in the acute phase of elder patients with asthma.