人体丝虫病微丝蚴观察

OBSERVATION ON THE BEHAVIOR OF MICROFILARIAE IN HUMAN FILARIASIS

取自25例丝虫病患者的26条丝虫雌虫,其中19条含微丝蚴,4条寄生在血管内,1条穿过静脉壁,血管内有成熟的微丝蚴,后者大多凝固在血栓中。游离在淋巴液和血液内的微丝蚴,有的引起大量嗜酸性和中性粒细胞浸润或形成血栓,并在实质性组织中形成肉芽肿。8条寄生在淋巴管的雌虫释出不成熟的微丝蚴和幼胚,进入血流后可成为微小栓子。当雌虫死亡时,子宫内成熟微丝蚴出现与成虫不同步性的退变。

A total of 19 female adult filarite containing microfilarke in uteri collected from 25 filariasis patients were examined. Light transmission microscopic observations showed: (1) some of the adult worms entered the lumen of blood vessels by penetrating the venous wall and discharged immature and mature microfilariae and embryos into the blood stream; (2) microfilariae developed into maturation in the uterus of adult female worms, but when the adult worm began to degenerate, the microfilariae did not degenerate concurrently; (3) some microfilariae could form thrombus, inducing the infiltration of segmented neutrophils and eosinophils followed by the formation of granuloma; (4) embryos 8 female adults parasitizing lymphatics were seen to discharge immature microfilariae and ova, which might form emboli after entering the blood stream.