miR-17-92基因簇在骨肉瘤中的表达及其临床意义

Expression of mi R-17-92 cluster in osteosarcoma and its clinical significance

目的:探讨人骨肉瘤组织和邻近正常骨组织中mi R-17-92基因簇的表达情况及其临床意义。方法:运用Q-PCR法检测63例骨肉瘤组织及邻近部位正常骨组织中mi R-17-92基因簇的表达水平,并分析mi R-17-92基因簇表达与患者临床病理特征及预后的关系。结果:mi R-17-92在所有组织中均有表达,且在肿瘤组织中表达明显高于在正常组织中的表达(P<0.05),另外,mi R-17-92基因簇高表达患者预后更差,差异有统计学意义(P=0.027)。结论:mi R-17-92基因簇在骨肉瘤组织和邻近正常骨组织中表达存在差异性,可能在骨肉瘤发生、发展过程中起重要作用,有望成为骨肉瘤患者预后一种新的指标。

Objective： To determine the expression of miR-17-92 cluster in osteosarcoma tissue samples and explore its associa- tion with clinical significance. Methods： Quantitative polymerase chain reactiom analysis was used to examine the expression of miR-17-92 cluster in osteosarcoma tissues. Normal bone tissues from 63 patients were matched, and the relationships between the ex- pression of miR-17-92 cluster and the clinicopathological features and prognosis of osteosarcoma were explored. Results： The relative expression of miR-17-92 cluster in osteosarcoma tissues was significantly higher than those in adjacent normal tissues （P〈0.05）. The high expression of miR-17-92 had a significant correlation with reduced survival （P=-0.027）. Conclusion： The expression of miR-17-92 cluster closely correlates with the occurrence and progress of osteosarcoma and may be used as an indicator for osteosarcoma prognosis.