平哮合剂对哮喘豚鼠模型肺组织MMP-9和TIMP-1水平的影响

Effects of Pingxiao Mixture on the Levels of MMP-9 and TIMP-1 in Lung Tissues of Allergic Asthmatic Model in Guinea Pig

目的:研究平哮合剂对过敏性哮喘豚鼠模型肺组织MMP-9和TIMP-1水平的影响。方法:采用卵蛋白造成过敏性哮喘豚鼠模型,给予平哮合剂后用ELISA法测定豚鼠肺组织MMP-9和TIMP-1水平,并计算MMP-9/TIMP-1比值。结果:平哮合剂能显著降低哮喘豚鼠模型肺组织MMP-9、TIMP-1水平和MMP-9/TIMP-1比值。结论:平哮合剂能通过平衡肺组织中MMP-9和TIMP-1水平起到治疗哮喘的作用。

Objective： To study the effects of Pingxiao mixture on the levels of MMP -9 and TIMP - 1 in lung tissues of allergic asthmatic model in guinea pig. Methods ： The allergic asthmatic model of guinea pig was in- duced by ovalbumin. Then the Pingxiao mixture was administered to the animals, and the levels of MMP -9 and TIMP - 1 in lung tissues were measured by ELISA, and the ratio of MMP -9/TIMP - 1 was calculated. Results ： Pingxiao mixture could decrease the levels of MMP - 9 and TIMP - 1 in lung tissues and the ratio of MMP -9/TIMP - 1 significantly. Conclusion： Pingxiao mixture could balance the levels of MMP - 9 and TIMP - 1 in lung tissues of allergic asthmatic model. Therefore, it provides an experimental basis for the clini- cal use of treating asthma.