BMPR1B基因在寒泊肉羊世代选育中的遗传变异及其与产羔性状的关联分析

Association of BMPR1B gene with litter size trait and genetic variations in different generations of Hanper mutton sheep

为了探讨BMPR1B(A746G)基因在寒泊肉羊世代选育中的遗传变异及其与产羔数的关系,本试验分析了不同选育世代寒泊肉羊BMPR1B基因型和基因频率,基因型对不同世代母羊产羔数的影响。结果表明BMPR1B基因突变纯合型BB个体从第一世代就开始出现,BB基因型频率随选育世代增加呈现增加趋势,从G1到G2世代,BB基因型频率显著增加。G1世代B+基因型母羊产羔数高于++基因型,但差异不显著。G2世代BB基因型母羊产羔数达到3.0,显著大于B+(1.89)和++(1.24)基因型个体(P<0.01)。G1和G2世代BMPR1B基因型母羊对初产日龄和产羔间隔均无显著影响(P>0.05)。结果提示BMPR1B基因作为分子标记可显著提高寒泊肉羊新种群母羊产羔数。

The aim of this study was to research the variation of BMPR1B （A746G） gene dur- ing generation selection and its association with litter size of Hanper mutton sheep. We ana- lyzed the genotypic and genic frequency of BMPR1B gene, and the effects of genotypes on lit- ter size of ewes during different selection generations. The results indicated that the individu- als of BB genotype homozygotes appeared in the first generation, and BB genotype and genic frequency increased with selected generations. The litter size of ewes with B＋genotype was greater than that of ewes with＋ ＋ genotype insignificantly in the first generation （G1） （P〉0.05） ,however, the litter size of BB ewe was 3.0, which was higher than those of B＋ （1.89） and ＋＋ （1.24） in the second generation （G2） remarkably （P〈0. 01）. There was no effect of BM- PR1B genotype on the first birthing age and birthing interval in G1 and G2 （P〉0.05）. The a-bore results demonstrated that BMPRIB gene increased the litter size of ewes from new flock Hanper mutton sheep as molecular marker.