重症疟疾相关分子机制的研究进展

Research progress on molecular mechanism of severe malaria

由恶性疟原虫感染引起的疟疾导致全球每年100余万病例死亡,其中以脑型疟为代表的重症疟疾是引起疟疾患者死亡的主要原因.目前在临床上对重症疟疾的诊断、病理学分析以及治疗策略方面已比较成熟,但是对重症疟疾发生和发展过程中涉及的分子机制尚未完全清楚.该文对重症疟疾相关的关键分子及其调控机制的研究进展作一综述.

Malaria caused by Plasmodium falciparum accounts for approximately one million deaths worldwide,most of whom are killed by severe malaria,particularly cerebral malaria （CM）.Currently,it has been well studied on the clinical diagnosis,pathological analysis and therapy strategies,however,little is known of the pathogenesis of severe malaria including the occurrence,development,and involved molecular mechanisms.Here the research advances on the severe malaria-related key molecules,regulatory factors,and pathways were reviewed and discussed.