蛋白质N~α-末端乙酰化的功能研究进展
摘要
蛋白质Nα-末端乙酰化修饰是由Nα-末端乙酰转移酶（NATs）所催化的酶促反应过程,其结果是蛋白质N-末端的α氨基接受来自于乙酰辅酶A（Ac Co A）的乙酰基。在真核生物中Nα-末端乙酰化是一种广泛存在的蛋白质修饰方式,大约有68%的酵母蛋白质和85%人蛋白质是Nα-乙酰化修饰的[1],但原核和古细菌蛋白却很少发生乙酰化。
出处
《中国医药生物技术》
2015年第2期172-174,共3页
Chinese Medicinal Biotechnology
参考文献29
-
1Hollebeke J, Van Damme P, Gevaert K. N-terminal acetylation and other functions of Nα-acetyltransferases. Biol Chem, 2012, 393(4): 291-298.
-
2Goetze S, Qeli E, Mosimann C, et al. Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol, 2009, 7(11):e1000236.
-
3Amesen T. Toward a functional understanding of protein N-terminal acetylation. PLoS Biol, 2011, 9(5):e1001074.
-
4Hwang CS, Shemorry A, Varshavsky A. N-terminal acetylation of cellular proteins creates specific degradation signals. Science, 2010, 327(5968):973-977.
-
5Tasaki T, Sriram SM, Park KS, et al. The N-end rule pathway. Annu Rev Biochem, 2012, 81:261-289.
-
6Shemorry A, Hwang CS, Varshavsky A. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol Cell, 2013, 50(4):540-551.
-
7Helbig AO, Rosati S, Pijnappel PW, et al. Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels. BMC Genomics, 2010, 11:685.
-
8Coulton AT, East DA, Galinska-Rakoczy A, et al. The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast. J Cell Sci, 2010, 123(19):3235-3243.
-
9Scott DC, Monda JK, Bennett EJ, et al. N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science, 2011,334(6056):674-678.
-
10Filippakopoulos P, Knapp S. The bromodomain interaction module. FEBS Lett, 2012, 586(17):2692-2704.
-
1李薇薇(综述),陈烨(审校).幽门螺杆菌与血液病的研究新进展[J].国际输血及血液学杂志,2009(5):447-450. 被引量：2
-
2吴磊,罗志刚,徐兵.乙酰辅酶A乙酰转移酶1在前列腺癌中的表达及临床意义[J].中南医学科学杂志,2016,44(3):293-295. 被引量：1
-
3黄忱,陈建华.蛋白质α-N-末端乙酰化修饰研究进展[J].中国医药生物技术,2013,8(4):299-302.
-
4研究表明:细菌蛋白可对抗癌症细胞[J].现代临床医学生物工程学杂志,2003,9(2):122-122.
-
5钟孝斌,白松,赵翔宇.ARD1与肿瘤相关性的研究进展[J].中国现代普通外科进展,2010,13(11):887-889.
-
6一滴血评估癌症疗效[J].抗癌之窗,2009,0(4):79-79.
-
7吴海星,张学东.Tubedown-1与视网膜新生血管[J].中国实用眼科杂志,2008,26(2):97-100.
-
8朱立宁,徐岷,张尤历.DNA甲基化与胰腺癌的研究进展[J].国际消化病杂志,2012,32(2):104-106. 被引量：1
-
9王培培,张翠英.hMLH1、DAPK基因启动子区甲基化与肺癌耐药的相关性[J].肿瘤研究与临床,2016,28(3):207-209. 被引量：1
-
10吴春利,耿小平,朱立新.DNA甲基化与胆囊癌[J].国际外科学杂志,2008,35(8):568-571.
