ω-3多不饱和脂肪酸对疾病炎症反应影响的Meta分析

Effects of ω-3 polyunsaturated fatty acids on inflammation: a meta-analysis

目的系统评价ω-3多不饱和脂肪酸对疾病炎症反应的影响。方法计算机检索Pub Med、Web of Science、EM base、CBM、中国学术期刊全文数据库(CNKI)、万方中文期刊全文数据库等数据库,检索时限从建库到2013年10月,纳入所有ω-3多不饱和脂肪酸对疾病炎症反应影响的随机对照试验,按照纳入排除标准选择文献、提取资料和进行质量评价后,采用Rev Man 5.2软件进行Meta分析。结果共纳入12个随机对照试验,合计600例患者。Meta分析结果显示:与对照组相比,ω-3多不饱和脂肪酸可降低患者的C反应蛋白(CRP)[MD=-13.06;95%CI(-24.79,-1.33),P=0.03]、白细胞介素(IL-6)[MD=-42.99;95%CI(-62.09,-16.97),P=0.001]、肿瘤坏死因子(TNF-α)[MD=-23.15;95%CI(-36.30,-1.00),P=0.000 6]水平,对白蛋白变化未见明显差异。结论ω-3多不饱和脂肪酸可降低患者C反应蛋白(CRP)、白细胞介素(IL-6)、肿瘤坏死因子(TNF-α)水平,能够有效减轻多种疾病患者术后或治疗后过度的炎性反应,改善患者治疗后营养状态和免疫功能,促进机体康复。

Objective To systematically evaluate the effect of omega-three（ ω-3） polyunsaturated fatty acids on inflammatory response. Methods Literature was retrieved by computer from electronic databases including Pub Med,Web of Science,EMbase,CBM,China National Knowledge Infrastructure（ CNKI）,Wanfang database since data establishment to October 2013. Randomized clinical trials（ RCTs） were included according to the inclusive and exclusive criteria and the quality was assessed. Meta analysis was conducted with Revman 5. 1 software. Results Twelve RCTs involving 600 patients were included. Metaanalysis showed that compared with the control group,ω-3 polyunsaturated fatty acids reduced C-reactive protein（ CRP） [MD =- 13. 06; 95% CI（- 24. 79,- 1. 33）,P = 0. 03],interleukin-6（ IL-6） [MD =- 42. 99; 95% CI（- 62. 09,- 16. 97）,P = 0. 001],tumor necrosis factor（ TNF-α） [MD =- 23. 15; 95% CI（-36. 30,- 1. 00）,P = 0. 000 6],but not albumin levels. Conclusion Omega-3 polyunsaturated fatty acids can reduce the levels of inflammation-related factors CRP,IL-6 and TNF-α.