幽门螺杆菌感染与十二指肠Brunner腺增生关系的病例对照研究

A Case-control Study on Relationship between Helicobacter pylori Infection and Duodenal Brunner's Gland Hyperplasia

背景：十二指肠Brunner腺增生的发病率低，其确切的病因和发病机制目前尚不明确。目的：探讨幽门螺杆菌（ Hp）感染与十二指肠Brunner腺增生的相关性。方法：纳入2005年10月-2013年12月新疆维吾尔自治区人民医院行胃镜检查并经病理确诊为十二指肠Brunner腺增生的患者96例。选取无十二指肠Brunner腺增生的患者270例作为对照组，采用14 C-尿素呼气试验（14 C-UBT）检测入选患者Hp感染情况。分析十二指肠Brunner腺增生与Hp感染的关系。结果：病例组中，Hp阳性者75例，Hp感染相对比例为3.57（75/21）；对照组中，Hp阳性者160例，Hp感染相对比例为1.45（160/110）。病例组与对照组Hp感染相对比例差异有统计学意义（χ^2=10.97，P=0.001）， Hp感染是十二指肠Brunner腺增生的危险因素（OR=2.46，95%CI：1.44～4.19）。结论：Hp感染可能与十二指肠Brunner腺增生的发生有关。

Background：The incidence of duodenal Brunner’s gland hyperplasia is low and the etiology and pathogenesis has not yet been clarified. Aims：To investigate the relationship between duodenal Brunner’s gland hyperplasia and Helicobacter pylori（ Hp ） infection. Methods：A total of 96 patients with duodenal Brunner ’s gland hyperplasia diagnosed by pathological examination from October 2005 to December 2013 at People’s Hospital of Xinjiang Uygur Autonomous Region were enrolled in this study,and 270 cases without duodenal Brunner’s gland hyperplasia were served as controls. Hp infection was detected by 14 C-urea breath test（ 14 C-UBT）. The relationship between duodenal Brunner’s gland hyperplasia and Hp infection was analyzed. Results：In the duodenal Brunner ’s gland hyperplasia group,75 patients were Hp positive,the proportion of Hp infection was 3. 57（ 75/21 ）. In the control group,110 cases were Hp positive,the proportion of Hp infection was 1. 45（160/110）. The difference between the two groups was statistically significant（χ^2 =10. 97,P=0. 001）. Hp infection was a risk factor of the genesis of duodenal Brunner’s gland hyperplasia（ OR=2. 46, 95% CI：1. 44-4. 19）. Conclusions：Hp infection may be related with the genesis of duodenal Brunner’s gland hyperplasia.