血清降钙素原水平在肝移植术后并发肺部感染患者中的诊断价值

The detection of procalcitonin in pneumonia patients after liver transplantation

目的探讨降钙素原(PCT)的检测对肝移植术后细菌性中老年肺炎患者临床诊断价值。方法回顾性分析该院22例行肝脏移植术后并发肺部感染的中老年患者,将其分为细菌性肺炎感染组和非细菌性肺炎感染组。提取两组患者发热初期及48 h血清,检测PCT和C反应蛋白(CRP)浓度,采用受试者工作特征曲线(ROC)评价并比较两组敏感性和特异性差异。结果 PCT在肝移植术后并发细菌性肺炎患者与非细菌性肺炎患者中的水平有统计学差异(P<0.05),CRP水平无统计学差异(P>0.05)。ROC曲线表明细菌性肺炎组和非细菌性肺炎组发热初期PCT和CRP敏感性及特异性均较差;但患者病情发展48 h后,PCT比CRP表现出更好的敏感性和特异性(100%vs 86%,87%vs 71%,P<0.05)。结论 PCT比CRP更能灵敏地检测到肝移植术后患者细菌性肺炎的发展及预后。

Objective To investigate the clinical diagnostic value of procalcitonin （PCT） after liver transplantation in older patients with bacterial pneumonia .Methods A retrospective analysis was performed on 22 old patients who got pneumonia infection after liver trans-plantation.The patients were divided into bacterial pneumonia infection and non-bacterial pneumonia groups .Extracted serums was used to detect PCT and C-reactive protein（CRP） at fever early and after 48 hours,the results were compared by ROC.Res ulst The level of PCT had statistically significant difference between the two groups （ P〈0.05 ） .The level of CRP had no significant difference （ P〉0.05 ） .ROC showed that sensitivity and specificity of PCT and CRP were poor ,but PCT showed better sensitivity and specificity （100%vs 86%,87%vs 71%, P〈0.05 ）.Con clusions PCT is more sensitive to detect the development of patients after liver transplantation with bacterial pneumo -nia,and provide better and rapid clinical diagnosis .