血清Th17和Treg细胞在银屑病性关节炎患者中的表达及作用机制被引量：2

下载PDF

导出

摘要目的探讨血清Th17和Treg细胞在银屑病性关节炎患者的表达及作用机制。方法选取2012年2月至2014年2月于该院风湿免疫科就诊的70例银屑病性关节炎患者(试验组)和30例正常人(对照组),采用酶联免疫吸附法(ELISA)检测两组个体中的白细胞介素(IL)-17和人转化生长因子(TGF)-β1的水平,并用流式细胞分析法检测外周血Th17细胞和Treg细胞亚群,比较两组个体中四个指标的差异。结果试验组患者血清IL-17水平、Th17细胞、Th17/Treg和Treg细胞均高于对照组(P<0.05);试验组TGF-β1水平低于对照组(P<0.05)。结论 Th17细胞及Treg细胞可能通过调节其分泌的IL-17和TGF-β1水平从而在银屑病性关节炎发病中发挥重要作用。

作者张秀英董砚奉董汉玉

机构地区淄博市中心医院风湿免疫科淄博市张店区人民医院泰山医学院

出处《中国老年学杂志》 CAS CSCD 北大核心 2014年第22期6374-6375,共2页 Chinese Journal of Gerontology

关键词银屑病性关节炎 TH17 TREG IL-17 TGF-β1

分类号 R758.63 [医药卫生—皮肤病学与性病学]

引文网络
相关文献

参考文献9

1陈晋广,赖维,姜昱.银屑病性关节炎患者Th17和Treg细胞的变化及意义[J].中国医学科学院学报,2012,34(6):617-620. 被引量：10
2Moon YM,Lee J,Lee SY,et al.Gene associated with retinoid-interferoninduced mortality 19 attenuates murine autoimmune arthritis by regulation of th17 and Treg cells[J].Arthritis Rheumatol,2014;66(3):569-78.
3李鑫,范洁琳.Th17/Treg细胞在银屑病的发病机制研究进展[J].现代生物医学进展,2012,12(24):4769-4772. 被引量：11
4陈诚,王佳,李义德,郑晓敏,张晓春.免疫性血小板减少症患儿外周血CD4+CD25+调节T细胞和Th17细胞的变化[J].宁夏医科大学学报,2013,35(8):864-867. 被引量：8
5陈晋广,姜昱.银屑病性关节炎患者Th17/Treg相关细胞因子的检测[J].中国皮肤性病学杂志,2012,26(11):969-970. 被引量：11
6Galati D,De Martino M,Trotta A,et al.Peripheral depletion of NK cells and imbalance of the Treg/Th17 axis in idiopathic pulmonary fibrosis patients[J].Cytokine,2014;66(2):119-26.
7童来根,吴文忠,周志刚,张云平,陈亚峰,黄文娟,许欢,苏倩倩.再生障碍性贫血外周血Th17和CD4^+ CD25^+ Treg细胞表达情况研究[J].中国实验血液学杂志,2013,21(4):974-978. 被引量：11
8Chevalier MF,Petitjean G,Dunyach-Remy C,et al.The Th17/Treg ratio,IL-1RA and s CD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation[J].PLo S Pathog,2013,9(6):e1003453.
9Ma Y,Yuan X,Deng L,et al.Imbalanced frequencies of Th17 and Treg cells in acute coronary syndromes are mediated by IL-6-STAT3 signaling[J].PLo S One,2013;8(8):e72804.

二级参考文献78

1FENGNing-han,WUHong-fei,WUJun,ZHANGWei,SUIYuan-gen,HEHou-guang,ZHANGChun-lei,ZHENGJun-song.Immunology Mechanism of CD4^＋ CD25^ T Regulatory Cells Acting on Effector T Cells[J].Journal of Nanjing Medical University,2004,18(4):178-182. 被引量：28
2黄花荣.小儿特发性血小板减少性紫癜临床疗效与骨髓巨核细胞数的关系[J].临床儿科杂志,2006,24(2):124-125. 被引量：10
3张强,李庆,徐静玮,张爱梅,徐修才,翟志敏.再生障碍性贫血患者T细胞亚群检测的临床意义[J].中国实验血液学杂志,2007,15(5):1046-1049. 被引量：33
4Sallusto F, Lanzavecchia A. Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity[J]. EurJ Immtmol, 2009, 39 (8): 2076-2082.
5Noma T. Helper T cell paradigm: Thl7 and regulatory T cells involved in autoimmune inflammatory disorders, pathogen defense and allergic diseases [J]. Nihon Rinsho Meneki Gakkai Kaishi, 2010, 33 (5): 262-271.
6Schn MP, Boehncke WH. Psoriasis[J]. N Engl J Med, 2005, 352(18): 1899-1912.
7Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental path- ways for the generation of pathogenic effector Thl 7 and regulatory T cells[J]. Nature, 2006, 441(7090): 235-238.
8Endong L, Shijie J, Sonobe Y, et al. The Gap-junction inhibitor Car- benoxolone suppresses the differentiation of Th 17 cells through inhi- bition of IL-23 expression in antigen presenting cells [J]. J Neuroim. munol, 2011,240-241:58-64.
9Afzali B, Lombardi G, Lechler RI, et al. The role of T helper 17 (Thl7) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease[J]. Clin Exp Immunol, 2007, 148(1): 32-46.
10Freyschmidt E J, Mathias CB, Diaz N, et al. Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses[J]. J Immunol, 2010, 185(2): 1295-1302.