双侧肺大泡同期胸腔镜外科治疗效果分析

Clinical Outcomes of Simultaneous Video-assisted h oracoscopic Surgery for Bilateral Giant Bullae

目的分析胸腔镜同期治疗双侧肺大泡的临床效果。方法回顾性分析新疆医科大学第一附属医院2011年3月至2013年4月手术治疗160例肺大泡患者的临床资料,根据肺大泡部位及手术方式分为A、B、C三组。A组(108例):自发性气胸、单侧肺大泡,行胸腔镜下单侧肺大泡切除术,其中男88例、女20例,年龄(31.36±16.14)岁;B组(40例):自发性气胸、有双侧肺大泡,行胸腔镜下气胸侧肺大泡切除术,其中男36例、女4例,年龄(37.63±18.84)岁;C组(12例):自发性气胸、双侧肺大泡,同期行胸腔镜下双侧肺大泡切除术;其中男9例、女3例,年龄(32.58±16.06)岁。分析三组患者并发症发生率及对侧气胸发生率。结果全组均顺利完成手术,随访20个月。A组术后发生急性肺水肿1例,胸腔粘连11例,呼吸衰竭2例,术后肺漏气5例;随访期间复发自发性气胸5例,其中同侧2例,对侧3例。B组术后发生胸腔粘连4例,呼吸衰竭1例,术后肺漏气3例;随访期间复发自发性气胸18例,其中同侧3例,对侧15例。C组术后发生胸腔粘连2例,术后肺漏气1例;随访期间同侧复发自发性气胸1例。A组及C组对侧气胸发生率均低于B组,差异有统计学意义(PAB=0.000,PBC=0.031)。结论同期胸腔镜手术预防性治疗对侧肺大泡,疗效满意,安全可靠,能有效预防对侧气胸的发生。

Objective To explore clinical outcomes of simutaneous video-assisted thoracoscopic surgery（VATS） for bilateral giant bullae（GB）. Methods Clinical data of 160 GB patients who received surgical treatment in the First Affiliated Hospital of Xinjiang Medical University from March 2011 to April 2013 were retrospectively analyzed. According to GB location and surgical strategies, all the patients were divided into 3 groups. In group A, there were 108 patients with spontaneous pneumothorax（SP） and unilateral GB who underwent unilateral GB resection with VATS, including 88 male and 20 female patients with their age of 31.36±16.14 years. In group B, there were 40 patients with SP and bilateral GB who underwent unilateral GB resection in the SP side with VATS, including 36 male and 4 female patients with their age of 37.63±18.84 years. In group C, there were 12 patients with SP and bilateral GB who underwent simultaneous bilateral GB resection with VATS, including 9 male and 3 female patients with their age of 32.58±16.06 years. Postoperative morbidity and SP recurrence rates were analyzed. Results All the operations were successfully performed, and patients were followed up for 20 months after discharge. In group A, postoperative complications included acute pulmonary edema in 1 patient, pleural adhesion in 11 patients, respiratory failure in 2 patients, and pulmonary air leak in 5 patients. During follow-up, SP recurred in 5 patients including 2 patients with SP recurrence at the same side and 3 patients with SP recurrence at the other side of thorax. In group B, postoperative complications included pleural adhesion in 4 patients, respiratory failure in 1 patient, and pulmonary air leak in 3 patients. During follow-up, SP recurred in 18 patients including3 patients with SP recurrence at the same side and 15 patients with SP recurrence at the other side of thorax. In group C, postoperative complications included pleural adhesion in 2 patients and pulmonary air leak in 1 patient. During follow-up,SP recurred in 1 patient at the same side of thorax. SP recurrence rates of group A and C were significantly lower than that of group B（P=0.000 and P=0.031 respectively）. Conclusion Simultaneous VATS is safe, efficacious and reliable for the treatment of bilateral GB, and can effectively prevent SP recurrence at the other side of thorax.