内质网应激相关机制及其在炎症性肠病中的作用

Related mechanisms of endoplasmic reticulum stress and its role in inflammatory bowel disease

肠内稳态在维持胃肠正常功能方面发挥重要作用。肠内环境改变时,肠内稳态失衡,影响肠上皮细胞(intestinal epithelial cells,IECs)内质网腔内蛋白质折叠。当IECs内错误折叠蛋白过多或未折叠蛋白反应(unfolded protein response,UPR)功能受损时,引起内质网应激(endoplasmic reticulum stress,ERS),导致肠黏膜受损,介导炎症性肠病(inflammatory bowel disease,IBD)发生。固有免疫应答、自噬过程与ERS相互影响,共同促进IBD发展。本文就ERS相关机制及其在IBD发生中的作用作一概述。

Intestinal homeostasis plays an important role in maintaining gastrointestinal function. When intestinal en- vironment changes, intestinal homeostasis is broken, influencing protein folding of endoplasmic reticulun （ER） lumen in intestinal epithelial cells （IECs）. Misfolded proteins accumulated in ER or unfolded protein response （UPR） impaired will cause the endoplasmic reticulum stress （ERS） , which lead to intestinal mucosal damage, involved in the pathogene- sis of inflammatory bowel disease （IBD）. Innate immune response, autophagy and ERS influence each other, commonly promote the development of IBD. In this review, the mechanisms of ERS and its role in IBD will be discussed.