结肠黑变病新进展

New progress of melanosis coli

结肠黑变病(melanosis coli,MC)是以结肠色素沉着为特征的代谢性而非炎症性疾病。其色素沉着主要与黏膜固有层内巨噬细胞含有脂褐素样物质有关。目前研究的重点多集中于MC的危险因素及其与结肠腺瘤、结肠癌等细胞增殖性疾病之间的关系。现针对国内外近年来关于MC的新进展作一概述,为临床医师的诊疗提供线索。

Melanosis coli （MC） is a metabolic disease characterised by a brownish pigmentation of the colonic mucosa in- stead of inflammatory. The pigmentation is mainly related to macrophages containing fat brown sample material in lamina pro- pria of colonic mucosa. Present studies more focus on the risk factors of MC, and the relationship between MC and some hy- perplastic diseases like colorectal carcinomas or coloreetal adenomas. This paper summarized MC related researehs in home and abroad recent years to provide new clues for clinicians in the diagnosis and treatment of MC.