非酒精性脂肪肝患者血清25-OH维生素D水平的变化

The changes of serum 25-OH vitamin D level in nonalcoholic fatty liver disease patients

目的探讨非酒精性脂肪肝(NAFLD)患者血浆25-OH维生素D(25-OH Vit D)水平变化。方法随机入组NAFLD患者50例,年龄匹配的健康对照者50例,留取血清及血浆标本测定血糖及血脂。使用液相色谱-质谱法测定血清25-OH Vit D水平。用t检验比较两组间各指标间的差异,用Spearman相关分析检测血清25-OH Vit D水平与NAFLD之间的相关性。结果 NAFLD组血清25-OH Vit D水平较健康对照组显著下降(P=0.03);25-OH Vit D水平与NAFLD明显相关(r=-0.128,P=0.002)。结论NAFLD患者存在25-OH Vit D缺乏,且低25-OH Vit D水平与NAFLD显著相关。

Objective To investigate the changes of circulating 25-hydroxy vitamin D （25-OH VitD） in nonalcoholic fatty liver disease （NAFLD） patients. Methods Fifty patients with NAFLD and 50 normal controls with age matched were randomly recruited. Their fasting serum and plasma samples were also collected for the measurement of serum lipids and plasma glucose. 25-OH VitD was measured by liquidchromatography/mass-spectrometric method. The data detected by t test. The correlation between 25-OH VitD and NAFLD was detected by Spearman analysis. Results The level of 25-OH VitD in NAFLD group was significantly lower than that in control group （ P = 0.03）. The level of 25-OH VitD was correlated with NAFLD （P = 0. 002）. Conclusion NAFLD are lack of 25-OH Vit D and the deficiency is associat- ed with the presence of NAFLD.